The Benefits of Tranexamic Acid in Simultaneous Bilateral TKA

    Most joint replacement surgeons use either intravenous or topical tranexamic acid during total knee arthroplasty (TKA) because it has been found to be efficacious in reducing transfusions and the associated costs and increased length of stay.

    That’s for a unilateral TKA. What about for simultaneous bilateral TKA?

    According to a study from Mayo Clinic – presented at the recent annual meeting of the Mid-America Orthopaedic Association – the benefits of using tranexamic acid extend to the bilateral procedure as well. Tranexamic acid during simultaneous bilateral TKA was associated with significant reductions in:

    • Transfusion rates: 25.6% with tranexamic acid and 61.5% without (P <0.0001)
    • Length of stay: Mean difference 0.97 days (P <0.001)
    • Mean hospital costs: Mean difference $1,857 (95% CI $1,028-$2,685)

    They did not observe an increase in 30-day thromboembolic events, one of the outcome measures of the study.

    We asked lead author Daniel R. Whiting, MD, to discuss the results of the study. Click the image above to hear his comments.

    Producer and Director: Michael Bugera; Post Production: Charles Maynard


    Whiting DR, Steward TM, Kremers HM, Duncan CM, Smith HM, Sierra RJ. Tranexamic Acid Decreases Transfusion and Hospital Cost in Simultaneous Bilateral Total Knee Arthroplasty (Paper 132). Presented at the Mid-America Orthopaedic Association Annual Meeting, April 22-25, 2015, Hilton Head Island, South Carolina.