Study Is Examining Hyaluronic Acid Plus Exercise Versus Exercise Alone for Knee OA
A multicenter study is underway to determine if combining hyaluronic acid injections and an exercise program is more beneficial for patients with knee osteoarthritis (OA) than exercise alone. The study agent is Hymovis, an FDA-approved hyaluronic acid product that is administered as 2 injections in the knee joint given 1 week apart.
“Research shows that certain exercise programs can benefit people with knee arthritis. However, not all patients obtain sufficient pain relief through exercise,” said Sabrina Strickland, MD, an orthopedic surgeon and lead investigator for Hospital for Special Surgery (HSS).
“The new study, which will take place at hospitals around the country including HSS, is designed to enroll a relatively young, active population of people with knee osteoarthritis. It will be interesting to see the results, as hyaluronic acid injections are typically used for an older patient population.”
Study participants will be divided into 2 groups:
- The first group will receive 2 hyaluronic acid injections combined with a physical exercise program of at least 8 weeks’ duration.
- The second group will be given only an 8-week exercise program.
All patients will receive a diary to record their activity and progress. They will see a physician for follow-up visits 3 and 6 months after study enrollment.
The initial examination, radiographs, hyaluronic acid injections, exercise program, and follow-up visits will all be provided free of charge to study participants. Patients who have failed to obtain sufficient pain relief from the exercise program alone at the 3-month follow-up will have the option of receiving the hyaluronic acid injections.
The study is open to individuals from ages 21 to 55 years who meet the following criteria, among others:
- Have had persistent knee pain for at least 3 months prior to the initial screening
- Lead an active lifestyle, defined as playing a sport or training at least 2 or 3 times per week
- Have been diagnosed with knee OA confirmed by radiographs
More information about the study can be found here.