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    ICJR Interviews: Liposomal Bupivacaine Affects LOS, Discharge Status

    Total knee arthroplasty (TKA) patients who received intraoperative infiltration of liposomal bupivacaine had a significantly decreased length of hospital stay and increased likelihood of being discharged home rather than to a care facility when compared with patients who received a standard analgesic regimen, according to data presented at the 2016 Annual Meeting of the American Academy of Orthopaedic Surgeons in Orlando.

    “The results of this analysis are encouraging because they suggest that the use of (liposomal bupivacaine) not only allows us to get our patients up and out of the hospital sooner, but also increases the likelihood we can send them directly home,” said Michael Mont, MD, director of the Center for Joint Preservation and Replacement at Sinai Hospital and an author on the poster.

    “The ability to recover at home, rather than in a short-term nursing facility or rehabilitation center, not only lends itself to favorable hospital economics, but also—importantly—toward a more comfortable patient recovery experience.”

    In this retrospective analysis, researchers reviewed data from the Premier hospital discharge database to identify patients ages 18 and older who underwent an inpatient TKA procedure between July 1, 2013, and June 30, 2014. The analysis compared 94,828 patients who had received either a standard analgesic regimen (80,160) or liposomal bupivacaine (14,668).

    Key findings for patients who received liposomal bupivacaine compared with the standard analgesic modalities included:

    • Nearly a half-day reduction in length of hospital stay (2.58 vs. 2.98 days, respectively; P<0.001)
    • More patients discharged directly to home rather than to an interim care facility (73.2% vs. 66.6%, respectively)
    • A greater likelihood of being discharged home, according to a logistic regression analysis (OR=1.49 for patients in the liposomal bupivacaine group; P<0.001).

    We asked Jaydev Mistry, MD, from the Rubin Institute for Advanced Orthopedics, Center for Joint Preservation and Replacement, at Sinai Hospital of Baltimore, Maryland, to discuss the findings and conclusions of the study, “Liposomal Bupivacaine Suspension Can Reduce Lengths of Stay and Improve Discharge Status of Patients Undergoing TKA” (Poster 132).

    Click the image above to hear his comments.

    Producer: Susan Doan-Johnson; Director: Michael Bugera; Post Production: Charles J. Maynard