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    ICJR Interviews: Evaluating Outcomes of DVT/PE Chemical Prophylaxis

    In a review of patient records from the Kaiser Permanente database, aspirin was found to be as effective as chemical prophylactic agents in preventing deep vein thrombosis (DVT) but not pulmonary embolism (PE) in patients who underwent primary total knee arthroplasty (TKA).

    Additionally, the chemical prophylactic agents, including fondaparinux, low molecular weight heparin, and vitamin K antagonist, were found to be as safe as aspirin in this patient cohort.

    The researchers examined outcomes of more than 30,000 TKA patients who had received chemical prophylactic agents to prevent DVT and PE between 2006 and 2013 at 38 Kaiser Permanente medical centers.

    Although aspirin was not as effective as the chemical prophylactic agents in preventing PE, it was not associated with a higher mortality rate.

    In an interview with ICJR, 2 of the study authors – Stefano A. Bini, MD, and Monti Khatod, MD – provide a thoughtful commentary on the implications of the study results.

    Click the image above to hear them discuss the study, “VTE Prophylaxis in Primary Total Knee Arthoplasty: An Examination of 30,499 Patients from a US Total Joint Registry” (Paper 302), which was presented at the 2016 Annual Meeting of the American Academy of Orthopaedic Surgeons in Orlando.

    Producer: Henrik B. Pedersen, MD; Director: Michael Bugera; Post Production: Charles J. Maynard