Evaluating Efficacy of TXA in a Unilateral and Bilateral TKA

    A great deal of recent research has demonstrated the efficacy of tranexamic acid (TXA) in reducing blood loss and decreasing the need for transufion following total knee arthroplasty (TKA).

    A recent study from Akron General Medical Center in Ohio has shown that TXA is beneficial not only for unilateral TKA, but also for simultaneous bilateral TKA procedures.

    Blake Daney, MD, and his colleagues at this community hospital retrospectively reviewed the charts of 248 (19 simultaneous bilateral) patients who underwent TKA before implementation of their TXA protocol and 64 (14 simultaneous bilateral) patients who underwent TKA after the protocol was in use.

    The standard TXA dose was 1000 mg, but the operating surgeon could order 1 or 2 doses. Primary outcome measures included transfusion requirement, number of units transfused, and presence of any complications.

    Overall, Dr. Daney and his colleagues saw an 8.01% reduction in their postoperative tranfusion rate (10.94% after TXA implementation vs. 18.95% before).

    The transfusion rate was 6% in unilateral TKA patients who received TXA versus 16.16% in patients who did not receive the drug. In patients who underwent simultaneous bilateral TKA, the transfusion rate was 28.57% for those who received TXA versus 52.63% for those who did not receive TXA.

    Click the image above to hear Dr. Daney’s comments on the study and its findings.

    Producer: Michael Szuch; Director: Michael Bugera; Post Production: Charles J. Maynard


    Daney B. Vrabec G, Einsporn R, Vrabec C. Effect of Tranexamic Acid on Post-Operative Total Knee Arthroplasty Blood Transfusions in the Community Hospital Setting. Presented at the 2nd Annual Pan Pacific Orthopaedic Congress, July 22-25, 2015, Kona Hawaii.