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    Are PRP and Stem Cells Appropriate for Treating Injuries in Young Athletes?

    Physicians should be cautious when considering treatment of injured young athletes with platelet rich plasma (PRP), stem cells, or other types of regenerative medicine, according to a study published Current Sports Medicine Reports, a journal of in the American College of Sports Medicine.

    “While regenerative medicine appears to have promise in many areas of medicine, little is known about the safety or effectiveness of these treatments for bone, cartilage, ligament, or muscle tissue injuries in children and adolescents,” said Thomas Best, MD, PhD, professor of orthopedics, family medicine, biomedical engineering, and kinesiology and team physician for the University of Miami athletics and the Miami Marlins.

    “Everyone wants a young athlete to get back to sports as quickly as possible, but it is important to look first at treatments that have been shown to be effective, before considering unproven options.”

    Dr. Best was the lead author of the study, “Not Missing the Future: A Call to Action for Investigating the Role of Regenerative Medicine Therapies in Pediatric/Adolescent Sports Injuries.”

    “Evidence from laboratory and veterinary research suggests that mesenchymal stem cells (MSC) may provide an alternative treatment option for conditions that affect muscle, tendons, ligaments, and cartilage,” said the authors.

    “This evidence, however, is based largely on studies in adults and it remains unknown whether these results will be duplicated in our younger populations.”

    Young athletes are vulnerable to a wide range of injuries, including overuse of arm, shoulder and leg muscles, ligaments, and joints in sports like baseball, tennis, soccer, and golf, Dr. Best said.

    “Unregulated clinics may sound attractive to parents and youngsters seeking aggressive regenerative therapy. But far more scientific research is necessary to determine if those treatments are helpful in overcoming sports injuries and, more importantly, without serious short- or long-term side effects.”

    The study had its genesis in an August 2016 meeting of sport medicine clinicians, researchers, and a bioethicist who felt that a call to action was urgently needed to understand the current evidence, risks and rewards, and future directions of research and clinical practice for regenerative medicine therapies in youth sports.

    The published report includes a 7-point call to action:

    • Exercise caution in treating youth with cell-based therapies as research continues.
    • Improve regulatory oversight of these emerging therapies.
    • Expand governmental and private research funding.
    • Create a system of patient registries to gather treatment and outcomes data.
    • Develop a multiyear policy and outreach agenda to increase public awareness.
    • Build a multidisciplinary consortium to gather data and promote systematic regulation.
    • Develop and pursue a clear collective impact agenda to address the “hype” surrounding regenerative medicine.

    Reflecting on the evidence, the study’s authors wrote, “Despite the media attention and perceived benefits of these therapies, there are still limited data as to efficacy and long-term safety. The involvement of clinicians, scientists and ethicists is essential in our quest for the truth.”

    Source

    Best TM, Caplan A, Coleman M, et al. Not missing the future: a call to action for investigating the role of regenerative medicine therapies in pediatric/adolescent sports injuries. Curr Sports Med Rep. 2017 May/Jun;16(3):202-210. doi: 10.1249/JSR.0000000000000357.